MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors.
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ABSTRACT:
SUBMITTER: Berwick M
PROVIDER: S-EPMC3988207 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
MITF E318K's effect on melanoma risk independent of, but modified by, other risk factors.
Berwick Marianne M MacArthur Jamie J Orlow Irene I Kanetsky Peter P Begg Colin B CB Luo Li L Reiner Anne A Sharma Ajay A Armstrong Bruce K BK Kricker Anne A Cust Anne E AE Marrett Loraine D LD Gruber Stephen B SB Anton-Culver Hoda H Zanetti Roberto R Rosso Stefano S Gallagher Richard P RP Dwyer Terence T Venn Alison A Busam Klaus K From Lynn L White Kirsten K Thomas Nancy E NE
Pigment cell & melanoma research 20140130 3
A rare germline variant in the microphthalmia-associated transcription factor (MITF) gene, E318K, has been reported as associated with melanoma. We confirmed its independent association with melanoma [odds ratio (OR) 1.7, 95% confidence interval (CI) = 1.1, 2.7, P = 0.03]; adjusted for age, sex, center, age × sex interaction, pigmentation characteristics, family history of melanoma, and nevus density). In stratified analyses, carriage of MITF E318K was associated with melanoma more strongly in p ...[more]
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