Ontology highlight
ABSTRACT:
SUBMITTER: Blevins T
PROVIDER: S-EPMC3988221 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Molecular cell 20140320 1
In Arabidopsis, multisubunit RNA polymerases IV and V orchestrate RNA-directed DNA methylation (RdDM) and transcriptional silencing, but what identifies the loci to be silenced is unclear. We show that heritable silent locus identity at a specific subset of RdDM targets requires HISTONE DEACETYLASE 6 (HDA6) acting upstream of Pol IV recruitment and siRNA biogenesis. At these loci, epigenetic memory conferring silent locus identity is erased in hda6 mutants such that restoration of HDA6 activity ...[more]