Ontology highlight
ABSTRACT:
SUBMITTER: Basile KJ
PROVIDER: S-EPMC3988223 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Basile Kevin J KJ Le Kaitlyn K Hartsough Edward J EJ Aplin Andrew E AE
Pigment cell & melanoma research 20140210 3
Vemurafenib and dabrafenib block MEK-ERK1/2 signaling and cause tumor regression in the majority of advanced-stage BRAF(V600E) melanoma patients; however, acquired resistance and paradoxical signaling have driven efforts for more potent and selective RAF inhibitors. Next-generation RAF inhibitors, such as PLX7904 (PB04), effectively inhibit RAF signaling in BRAF(V600E) melanoma cells without paradoxical effects in wild-type cells. Furthermore, PLX7904 blocks the growth of vemurafenib-resistant B ...[more]