CSF Apo-E levels associate with cognitive decline and MRI changes.
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ABSTRACT:
SUBMITTER: Toledo JB
PROVIDER: S-EPMC3988233 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
CSF Apo-E levels associate with cognitive decline and MRI changes.
Toledo Jon B JB Da Xiao X Weiner Michael W MW Wolk David A DA Xie Sharon X SX Arnold Steven E SE Davatzikos Christos C Shaw Leslie M LM Trojanowski John Q JQ
Acta neuropathologica 20140103 5
Apolipoprotein E (APOE) ε4 allele is the most important genetic risk factor for Alzheimer's disease (AD) and it is thought to do so by modulating levels of its product, apolipoprotein E (Apo-E), and regulating amyloid-β (Aβ) clearance. However, information on clinical and biomarker correlates of Apo-E proteins is scarce. We examined the relationship of cerebrospinal fluid (CSF) and plasma Apo-E protein levels, and APOE genotype to cognition and AD biomarker changes in 311 AD neuroimaging initiat ...[more]
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