Ontology highlight
ABSTRACT:
SUBMITTER: Zhao K
PROVIDER: S-EPMC3988314 | biostudies-literature | 2013 Sep
REPOSITORIES: biostudies-literature
Zhao Ke K Du Juan J Han Xue X Goodier John L JL Li Peng P Zhou Xiaohong X Wei Wei W Evans Sean L SL Li Linzhang L Zhang Wenyan W Cheung Ling E LE Wang Guanjun G Kazazian Haig H HH Yu Xiao-Fang XF
Cell reports 20130912 6
Long interspersed elements 1 (LINE-1) occupy at least 17% of the human genome and are its only active autonomous retrotransposons. However, the host factors that regulate LINE-1 retrotransposition are not fully understood. Here, we demonstrate that the Aicardi-Goutières syndrome gene product SAMHD1, recently revealed to be an inhibitor of HIV/simian immunodeficiency virus (SIV) infectivity and neutralized by the viral Vpx protein, is also a potent regulator of LINE-1 and LINE-1-mediated Alu/SVA ...[more]