Ontology highlight
ABSTRACT:
SUBMITTER: He CH
PROVIDER: S-EPMC3988532 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
Cell reports 20130822 4
Members of the 18 glycosyl hydrolase (GH 18) gene family have been conserved over species and time and are dysregulated in inflammatory, infectious, remodeling, and neoplastic disorders. This is particularly striking for the prototypic chitinase-like protein chitinase 3-like 1 (Chi3l1), which plays a critical role in antipathogen responses where it augments bacterial killing while stimulating disease tolerance by controlling cell death, inflammation, and remodeling. However, receptors that media ...[more]