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Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting.

ABSTRACT: Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-expressing tumor xenografts in mice, validating targeted CPMV as a nanoparticle platform in vivo.

SUBMITTER: Brunel FM 

PROVIDER: S-EPMC3988696 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Hydrazone ligation strategy to assemble multifunctional viral nanoparticles for cell imaging and tumor targeting.

Brunel Florence M FM   Lewis John D JD   Destito Giuseppe G   Steinmetz Nicole F NF   Manchester Marianne M   Stuhlmann Heidi H   Dawson Philip E PE  

Nano letters 20100301 3

Multivalent nanoparticle platforms are attractive for biomedical applications because of their improved target specificity, sensitivity, and solubility. However, their controlled assembly remains a considerable challenge. An efficient hydrazone ligation chemistry was applied to the assembly of Cowpea mosaic virus (CPMV) nanoparticles with individually tunable levels of a VEGFR-1 ligand and a fluorescent PEGylated peptide. The nanoparticles recognized VEGFR-1 on endothelial cell lines and VEGFR1-  ...[more]