Ontology highlight
ABSTRACT:
SUBMITTER: Cheng CY
PROVIDER: S-EPMC3988786 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Cheng Chieh-Yang CY Hwang Chang-Il CI Corney David C DC Flesken-Nikitin Andrea A Jiang Longchang L Öner Gülfem Meryem GM Munroe Robert J RJ Schimenti John C JC Hermeking Heiko H Nikitin Alexander Yu AY
Cell reports 20140313 6
The miR-34 family was originally found to be a direct target of p53 and is a group of putative tumor suppressors. Surprisingly, mice lacking all mir-34 genes show no increase in cancer formation by 18 months of age, hence placing the physiological relevance of previous studies in doubt. Here, we report that mice with prostate epithelium-specific inactivation of mir-34 and p53 show expansion of the prostate stem cell compartment and develop early invasive adenocarcinomas and high-grade prostatic ...[more]