Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC3989074 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kim Hyungjin H Dejsuphong Donniphat D Adelmant Guillaume G Ceccaldi Raphael R Yang Kailin K Marto Jarrod A JA D'Andrea Alan D AD
Molecular cell 20140320 1
Timely DNA replication across damaged DNA is critical for maintaining genomic integrity. Translesion DNA synthesis (TLS) allows bypass of DNA lesions using error-prone TLS polymerases. The E3 ligase RAD18 is necessary for proliferating cell nuclear antigen (PCNA) monoubiquitination and TLS polymerase recruitment; however, the regulatory steps upstream of RAD18 activation are less understood. Here, we show that the UBZ4 domain-containing transcriptional repressor ZBTB1 is a critical upstream regu ...[more]