Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC3989290 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Wang Wei W Deng Zhiyong Z Hatcher Heather H Miller Lance D LD Di Xiumin X Tesfay Lia L Sui Guangchao G D'Agostino Ralph B RB Torti Frank M FM Torti Suzy V SV
Cancer research 20131127 2
Experimental and epidemiologic evidence suggests that dysregulation of proteins involved in iron metabolism plays a critical role in cancer. The mechanisms by which cancer cells alter homeostatic iron regulation are just beginning to be understood. Here, we demonstrate that iron regulatory protein 2 (IRP2) plays a key role in iron accumulation in breast cancer. Although both IRP1 and IRP2 are overexpressed in breast cancer, the overexpression of IRP2, but not IRP1, is associated with decreased f ...[more]