Ontology highlight
ABSTRACT:
SUBMITTER: Verstrepen BE
PROVIDER: S-EPMC3989318 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Verstrepen Babs E BE Verschoor Ernst J EJ Fagrouch Zahra C ZC Mooij Petra P de Groot Natasja G NG Bontrop Ronald E RE Bogers Willy M WM Heeney Jonathan L JL Koopman Gerrit G
PloS one 20140416 4
A single correlate of effective vaccine protection against chronic HCV infection has yet to be defined. In this study, we analyzed T-cell responses in four chimpanzees, immunized with core-E1-E2-NS3 and subsequently infected with HCV1b. Viral clearance was observed in one animal, while the other three became chronically infected. In the animal that cleared infection, NS3-specific CD8 T-cell responses were observed to be more potent in terms of frequency and polyfunctionality of cytokine producin ...[more]