Ontology highlight
ABSTRACT:
SUBMITTER: Cochran JN
PROVIDER: S-EPMC3989444 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Brain research bulletin 20131212
Converging evidence indicates that processes occurring in and around neuronal dendrites are central to the pathogenesis of Alzheimer's disease. These data support the concept of a "dendritic hypothesis" of AD, closely related to the existing synaptic hypothesis. Here we detail dendritic neuropathology in the disease and examine how Aβ, tau, and AD genetic risk factors affect dendritic structure and function. Finally, we consider potential mechanisms by which these key drivers could affect dendri ...[more]