Ontology highlight
ABSTRACT:
SUBMITTER: Katt WP
PROVIDER: S-EPMC3989473 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Katt William P WP Cerione Richard A RA
Drug discovery today 20131016 4
Metabolism is the process by which cells convert relatively simple extracellular nutrients into energy and building blocks necessary for their growth and survival. In cancer cells, metabolism is dramatically altered compared with normal cells. These alterations are known as the Warburg effect. One consequence of these changes is cellular addiction to glutamine. Because of this, in recent years the enzyme glutaminase has become a key target for small molecule therapeutic intervention. Like many o ...[more]