Ontology highlight
ABSTRACT:
SUBMITTER: Wong AB
PROVIDER: S-EPMC3989618 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Wong Aaron B AB Rutherford Mark A MA Gabrielaitis Mantas M Pangrsic Tina T Göttfert Fabian F Frank Thomas T Michanski Susann S Hell Stefan S Wolf Fred F Wichmann Carolin C Moser Tobias T
The EMBO journal 20140117 3
Cochlear inner hair cells (IHCs) develop from pre-sensory pacemaker to sound transducer. Here, we report that this involves changes in structure and function of the ribbon synapses between IHCs and spiral ganglion neurons (SGNs) around hearing onset in mice. As synapses matured they changed from holding several small presynaptic active zones (AZs) and apposed postsynaptic densities (PSDs) to one large AZ/PSD complex per SGN bouton. After the onset of hearing (i) IHCs had fewer and larger ribbons ...[more]