Arrestin makes T cells stop and become active.
Ontology highlight
ABSTRACT:
SUBMITTER: Gurevich VV
PROVIDER: S-EPMC3989646 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Publications
Arrestin makes T cells stop and become active.
Gurevich Vsevolod V VV Gurevich Eugenia V EV
The EMBO journal 20140206 6
T-cell activation requires signaling by T-cell receptors (TCRs) that bind antigen on the antigen-presenting cells (APCs) at the immunological synapse (IS). Sustained signaling requires continuous supply of new TCRs to the IS. In this issue of The EMBO Journal, Fernández-Arenas et al (2014) describe a novel role of β-arrestin-1 at the IS periphery: endocytosis of TCRs and chemokine CXCR4 receptors. Internalized TCRs are then delivered to the IS, where they engage antigen and support prolonged sig ...[more]
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