Ontology highlight
ABSTRACT:
SUBMITTER: Hersman EM
PROVIDER: S-EPMC3989799 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Hersman Elisabeth M EM Bumpus Namandjé N NN
The Journal of pharmacology and experimental therapeutics 20140304 2
The cytochrome P450 (P450) superfamily of enzymes plays a prominent role in drug metabolism. Although mice are a widely used preclinical model in pharmacology, the expression of murine P450 enzymes at the protein level has yet to be fully defined. Twenty-seven proteins belonging to P450 subfamilies 1A, 2A, 2B, 2C, 2D, 2E, 2F, 2J, 2U, 3A, 4A, 4B, 4F, and 4V were readily detectable in Balb/c mouse tissue using a global mass spectrometry-based proteomics approach. Subsequently, a targeted mass spec ...[more]