Ontology highlight
ABSTRACT:
SUBMITTER: Smit JJ
PROVIDER: S-EPMC3989860 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
The RING-in-between-RING (RBR) E3s are a curious family of ubiquitin E3-ligases, whose mechanism of action is unusual in several ways. Their activities are auto-inhibited, causing a requirement for activation by protein-protein interactions or posttranslational modifications. They catalyse ubiquitin conjugation by a concerted RING/HECT-like mechanism in which the RING1 domain facilitates E2-discharge to directly form a thioester intermediate with a cysteine in RING2. This short-lived, HECT-like ...[more]