Whole-genome analysis in Korean patients with autoimmune myasthenia gravis.

ABSTRACT:

Purpose

The underlying cause of myasthenia gravis (MG) is unknown, although it likely involves a genetic component. However, no common genetic variants have been unequivocally linked to autoimmune MG. We sought to identify the genetic variants associated with an increased or decreased risk of developing MG in samples from a Korean Multicenter MG Cohort.

Materials and methods

To determine new genetic targets related to autoimmune MG, a whole genome-based single nucleotide polymorphisms (SNP) analysis was conducted using an Axiom™ Genome-Wide ASI 1 Array, comprising 598375 SNPs and samples from 109 MG patients and 150 neurologically normal controls.

Results

In total, 641 SNPs from five case-control associations showed p-values of less than 10⁻⁵. From regional analysis,

SUBMITTER: Na SJ 

PROVIDER: S-EPMC3990093 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature