Ontology highlight
ABSTRACT:
SUBMITTER: Henriques-Pons A
PROVIDER: S-EPMC3990161 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Henriques-Pons Andrea A Yu Qing Q Rayavarapu Sree S Cohen Tatiana V TV Ampong Beryl B Cha Hee Jae HJ Jahnke Vanessa V Van der Meulen Jack J Wang Daqing D Jiang Weiwen W Kandimalla Ekambar R ER Agrawal Sudhir S Spurney Chistopher F CF Nagaraju Kanneboyina K
Human molecular genetics 20131223 10
Although the cause of Duchenne muscular dystrophy (DMD) is known, the specific factors that initiate and perpetuate disease progression are not well understood. We hypothesized that leaky dystrophin-deficient skeletal muscle releases endogenous danger signals (TLR ligands), which bind to Toll-like receptors (TLRs) on muscle and immune cells and activate downstream processes that facilitate degeneration and regeneration in dystrophic skeletal muscle. Here, we demonstrate that dystrophin-deficient ...[more]