Ontology highlight
ABSTRACT:
SUBMITTER: Funkhouser WK
PROVIDER: S-EPMC3990650 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Funkhouser W Keith WK Niethammer Marc M Carson Johnny L JL Burns Kimberlie A KA Knowles Michael R MR Leigh Margaret W MW Zariwala Maimoona A MA Funkhouser William K WK
Ultrastructural pathology 20130819 4
Abstract Diagnosis of primary ciliary dyskinesia (PCD) by identification of dynein arm loss in transmission electron microscopy (TEM) images can be confounded by high background noise due to random electron-dense material within the ciliary matrix, leading to diagnostic uncertainty even for experienced morphologists. The authors developed a novel image analysis tool to average the axonemal peripheral microtubular doublets, thereby increasing microtubular signal and reducing random background noi ...[more]