Immunotoxins for leukemia.
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ABSTRACT:
SUBMITTER: Wayne AS
PROVIDER: S-EPMC3990911 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
Immunotoxins for leukemia.
Wayne Alan S AS Fitzgerald David J DJ Kreitman Robert J RJ Pastan Ira I
Blood 20140227 16
Unconjugated monoclonal antibodies that target hematopoietic differentiation antigens have been developed to treat hematologic malignancies. Although some of these have activity against chronic lymphocytic leukemia and hairy cell leukemia, in general, monoclonal antibodies have limited efficacy as single agents in the treatment of leukemia. To increase their potency, the binding domains of monoclonal antibodies can be attached to protein toxins. Such compounds, termed immunotoxins, are delivered ...[more]
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