Ontology highlight
ABSTRACT:
SUBMITTER: Bedzhov I
PROVIDER: S-EPMC3991392 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Cell 20140213 5
Transformation of pluripotent epiblast cells into a cup-shaped epithelium as the mouse blastocyst implants is a poorly understood and yet key developmental step. Studies of morphogenesis in embryoid bodies led to the current belief that it is programmed cell death that shapes the epiblast. However, by following embryos developing in vivo and in vitro, we demonstrate that not cell death but a previously unknown morphogenetic event transforms the amorphous epiblast into a rosette of polarized cell ...[more]