Ontology highlight
ABSTRACT:
SUBMITTER: Fiandalo MV
PROVIDER: S-EPMC3991464 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Fiandalo Michael V MV Wu Wenjie W Mohler James L JL
Current drug targets 20130401 4
Prostate cancer (CaP) is the most frequently diagnosed cancer and leading cause of cancer death in American men. Almost all men present with advanced CaP and some men who fail potentially curative therapy are treated with androgen deprivation therapy (ADT). ADT is not curative and CaP recurs as the lethal phenotype. The goal of this review is to apply our current understanding of CaP and castration-recurrent CaP (CR-CaP) to earlier studies that characterized ADT and the molecular mechanisms that ...[more]