Ontology highlight
ABSTRACT:
SUBMITTER: Razavian M
PROVIDER: S-EPMC3991560 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Razavian Mahmoud M Nie Lei L Challa Azariyas A Zhang Jiasheng J Golestani Reza R Jung Jae-Joon JJ Robinson Simon S Sadeghi Mehran M MM
Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology 20131225 2
<h4>Background</h4>Lipid lowering is a mainstay of modern therapeutic approach to atherosclerosis. We sought to evaluate matrix metalloproteinase (MMP)-targeted microSPECT imaging for tracking of the effect of lipid-lowering interventions on plaque biology in atherosclerotic mice in vivo.<h4>Methods and results</h4>ApoE(-/-) mice fed on a high fat diet (HFD) for 2 months were randomly assigned to continuation of HFD, HFD plus simvastatin, HFD plus fenofibrate and high fat withdrawal (HFW). The a ...[more]