Ontology highlight
ABSTRACT:
SUBMITTER: Hsueh YC
PROVIDER: S-EPMC3992076 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Hsueh Ying-Chang YC Wu Jasmine M F JM Yu Chun-Keung CK Wu Kenneth K KK Hsieh Patrick C H PC
EMBO molecular medicine 20140121 4
Although self-renewal ability of adult mammalian heart has been reported, few pharmacological treatments are known to promote cardiomyocyte regeneration after injury. In this study, we demonstrate that the critical period of stem/progenitor cell-mediated cardiomyocyte replenishment is initiated within 7 days and saturates on day 10 post-infarction. Moreover, blocking the inflammatory reaction with COX-2 inhibitors may also reduce the capability of endogenous stem/progenitor cells to repopulate l ...[more]