Ontology highlight
ABSTRACT:
SUBMITTER: Courties G
PROVIDER: S-EPMC3992176 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Courties Gabriel G Heidt Timo T Sebas Matthew M Iwamoto Yoshiko Y Jeon Derrick D Truelove Jessica J Tricot Benoit B Wojtkiewicz Greg G Dutta Partha P Sager Hendrik B HB Borodovsky Anna A Novobrantseva Tatiana T Klebanov Boris B Fitzgerald Kevin K Anderson Daniel G DG Libby Peter P Swirski Filip K FK Weissleder Ralph R Nahrendorf Matthias M
Journal of the American College of Cardiology 20131218 15
<h4>Objectives</h4>The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post-myocardial infarction (MI) remodeling.<h4>Background</h4>In healing wounds, the M1 toward M2 macrophage phenotype transition supports resolution of inflammation and tissue repair. Persistence of inflammatory M1 macrophages may derail healing and compromise organ functions. The transcription fac ...[more]