Ontology highlight
ABSTRACT:
SUBMITTER: He Y
PROVIDER: S-EPMC3992203 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
He Yang Y Brunstrom-Hernandez Janice E JE Thio Liu Lin LL Lackey Shellie S Gaebler-Spira Deborah D Kuroda Maxine M MM Stashinko Elaine E Hoon Alexander H AH Vargus-Adams Jilda J Stevenson Richard D RD Lowenhaupt Stephanie S McLaughlin John F JF Christensen Ana A Dosa Nienke P NP Butler Maureen M Schwabe Aloysia A Lopez Christina C Roge Desiree D Kennedy Diane D Tilton Ann A Krach Linda E LE Lewandowski Andrew A Dai Hongying H Gaedigk Andrea A Leeder J Steven JS Jusko William J WJ
The Journal of pediatrics 20140305 5
<h4>Objective</h4>To characterize the population pharmacokinetics (PK) of oral baclofen and assess impact of patient-specific covariates in children with cerebral palsy (CP) in order to support its clinical use.<h4>Subjects design</h4>Children (2-17 years of age) with CP received a dose of titrated oral baclofen from 2.5 mg 3 times a day to a maximum tolerated dose of up to 20 mg 4 times a day. PK sampling followed titration of 10-12 weeks. Serial R- and S-baclofen plasma concentrations were mea ...[more]