RNAi targeting GPR4 influences HMEC-1 gene expression by microarray analysis.
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ABSTRACT:
SUBMITTER: Ren J
PROVIDER: S-EPMC3992399 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Publications
RNAi targeting GPR4 influences HMEC-1 gene expression by microarray analysis.
Ren Juan J Zhang Yuelang Y Cai Hui H Ma Hongbing H Zhao Dongli D Zhang Xiaozhi X Li Zongfang Z Wang Shufeng S Wang Jiangsheng J Liu Rui R Li Yi Y Qian Jiansheng J Wei Hongxia H Niu Liying L Liu Yan Y Xiao Lisha L Ding Muyang M Jiang Shiwen S
International journal of clinical and experimental medicine 20140315 3
G-protein coupled receptor 4 (GPR4) belongs to a protein family comprised of 3 closely related G protein-coupled receptors. Recent studies have shown that GPR4 plays important roles in angiogenesis, proton sensing, and regulating tumor cells as an oncogenic gene. How GPR4 conducts its functions? Rare has been known. In order to detect the genes related to GPR4, microarray technology was employed. GPR4 is highly expressed in human vascular endothelial cell HMEC-1. Small interfering RNA against GP ...[more]
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