Ontology highlight
ABSTRACT:
SUBMITTER: Streichan SJ
PROVIDER: S-EPMC3992650 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Streichan Sebastian J SJ Hoerner Christian R CR Schneidt Tatjana T Holzer Daniela D Hufnagel Lars L
Proceedings of the National Academy of Sciences of the United States of America 20140331 15
Control of cell proliferation is a fundamental aspect of tissue formation in development and regeneration. Cells experience various spatial and mechanical constraints depending on their environmental context in the body, but we do not fully understand if and how such constraints influence cell cycle progression and thereby proliferation patterns in tissues. Here, we study the impact of mechanical manipulations on the cell cycle of individual cells within a mammalian model epithelium. By monitori ...[more]