Ontology highlight
ABSTRACT:
SUBMITTER: Kuniyoshi K
PROVIDER: S-EPMC3992669 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kuniyoshi Kanako K Takeuchi Osamu O Pandey Surya S Satoh Takashi T Iwasaki Hidenori H Akira Shizuo S Kawai Taro T
Proceedings of the National Academy of Sciences of the United States of America 20140327 15
The RIG-I-like receptors, retinoic acid inducible gene-1 (RIG-I), melanoma differentiation-associated protein 5, and laboratory of genetics and physiology-2, are cytoplasmic sensors for RNA viruses that mediate the antiviral innate immune responses. We demonstrate that really interesting new gene-finger domain- and K homology domain-containing MEX3C regulates RIG-I function. MEX3C colocalizes with RIG-I in the stress granules of virally infected cells, and its overexpression causes the lysine-63 ...[more]