The docking protein FRS2? is a critical regulator of VEGF receptors signaling.
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ABSTRACT:
SUBMITTER: Chen PY
PROVIDER: S-EPMC3992672 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Publications
The docking protein FRS2α is a critical regulator of VEGF receptors signaling.
Chen Pei-Yu PY Qin Lingfeng L Zhuang Zhen W ZW Tellides George G Lax Irit I Schlessinger Joseph J Simons Michael M
Proceedings of the National Academy of Sciences of the United States of America 20140402 15
Vascular endothelial growth factors (VEGFs) signal via their cognate receptor tyrosine kinases designated VEGFR1-3. We report that the docking protein fibroblast growth factor receptor substrate 2 (FRS2α) plays a critical role in cell signaling via these receptors. In vitro FRS2α regulates VEGF-A and VEGF-C-dependent activation of extracellular signal-regulated receptor kinase signaling and blood and lymphatic endothelial cells migration and proliferation. In vivo endothelial-specific deletion o ...[more]
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