Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.
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ABSTRACT:
SUBMITTER: Conn CS
PROVIDER: S-EPMC3992710 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
Nutrient signaling in protein homeostasis: an increase in quantity at the expense of quality.
Conn Crystal S CS Qian Shu-Bing SB
Science signaling 20130416 271
The discovery that rapamycin extends the life span of diverse organisms has triggered many studies aimed at identifying the underlying molecular mechanisms. Mammalian target of rapamycin complex 1 (mTORC1) regulates cell growth and may regulate organismal aging by controlling mRNA translation. However, how inhibiting mTORC1 and decreasing protein synthesis can extend life span remains an unresolved issue. We showed that constitutively active mTORC1 signaling increased general protein synthesis b ...[more]
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