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Fluorous enzymatic synthesis of phosphatidylinositides.

ABSTRACT: A fluorous tagging strategy coupled with enzymatic synthesis is introduced to efficiently synthesize multiple phosphatidylinositides, which are then directly immobilized on a fluorous polytetrafluoroethylene (PTFE) membrane to probe protein-lipid interactions.

SUBMITTER: Huang W 

PROVIDER: S-EPMC3993006 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature

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Fluorous enzymatic synthesis of phosphatidylinositides.

Huang Weigang W   Proctor Angela A   Sims Christopher E CE   Allbritton Nancy L NL   Zhang Qisheng Q  

Chemical communications (Cambridge, England) 20140205 22

A fluorous tagging strategy coupled with enzymatic synthesis is introduced to efficiently synthesize multiple phosphatidylinositides, which are then directly immobilized on a fluorous polytetrafluoroethylene (PTFE) membrane to probe protein-lipid interactions. ...[more]

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