Ontology highlight
ABSTRACT:
SUBMITTER: Ashrin MN
PROVIDER: S-EPMC3993049 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Ashrin Meinar Nur MN Arakaki Rieko R Yamada Akiko A Kondo Tomoyuki T Kurosawa Mie M Kudo Yasusei Y Watanabe Megumi M Ichikawa Tetsuo T Hayashi Yoshio Y Ishimaru Naozumi N
Journal of immunology (Baltimore, Md. : 1950) 20140326 9
Ni is the most frequent cause of contact allergy induced by metals. However, the underlying mechanism of this induction is unknown. Our previous research demonstrates that activation of dendritic cells (DCs) through p38MAPK/MKK6 is required for Ni-induced allergy in mice. In the current study, we investigated the cellular and molecular mechanisms underlying Ni-induced allergy using a mouse model that involves injecting Ni into the ear, with or without Freund's incomplete or complete adjuvants. N ...[more]