Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC3993091 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Liu Yanhong Y Zhou Renke R Baumbusch Lars O LO Tsavachidis Spyros S Brewster Abenaa M AM Do Kim-Anh KA Sahin Aysegul A Hortobagyi Gabriel N GN Taube Joseph H JH Mani Sendurai A SA Aarøe Jørgen J Wärnberg Fredrik F Børresen-Dale Anne-Lise AL Mills Gordon B GB Thompson Patricia A PA Bondy Melissa L ML
Breast cancer research and treatment 20131204 1
The aim of this study is to identify and validate copy number aberrations in early-stage primary breast tumors associated with bone or non-bone metastasis. Whole-genome molecular inversion probe arrays were used to evaluate copy number imbalances (CNIs) in breast tumors from 960 early-stage patients with information about site of metastasis. The CoxBoost algorithm was used to select metastasis site-related CNIs and to fit a Cox proportional hazards model. Gains at 1q41 and 1q42.12 and losses at ...[more]