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OXA-253, a variant of the carbapenem-hydrolyzing class D ?-lactamase OXA-143 in Acinetobacter baumannii.

ABSTRACT: The carbapenem-hydrolyzing class D ?-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 gene shares the highest identity with ubiquitous GR2 group plasmids usually carrying blaOXA-24/-40 genes.

SUBMITTER: Girlich D

PROVIDER: S-EPMC3993228 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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OXA-253, a variant of the carbapenem-hydrolyzing class D β-lactamase OXA-143 in Acinetobacter baumannii.

Girlich Delphine D Damaceno Quésia S QS Oliveira Adriana Cristina AC Nordmann Patrice P

Antimicrobial agents and chemotherapy 20140303 5

The carbapenem-hydrolyzing class D β-lactamase OXA-253 was identified in an Acinetobacter baumannii clinical isolate belonging to sequence type 113 (ST113) in Brazil. OXA-253 shares 93.8% amino acid identity with OXA-143. The blaOXA-253 gene is located on a ca. 20-kb plasmid. The genetic environment of the blaOXA-253 gene shares the highest identity with ubiquitous GR2 group plasmids usually carrying blaOXA-24/-40 genes. ...[more]

PMID: 24590480

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