Ontology highlight
ABSTRACT:
SUBMITTER: Kioumourtzoglou D
PROVIDER: S-EPMC3993566 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Kioumourtzoglou Dimitrios D Gould Gwyn W GW Bryant Nia J NJ
Molecular and cellular biology 20140127 7
Insulin stimulates glucose transport into fat and muscle cells by increasing the exocytic trafficking rate of the GLUT4 facilitative glucose transporter from intracellular stores to the plasma membrane. Delivery of GLUT4 to the plasma membrane is mediated by formation of functional SNARE complexes containing syntaxin4, SNAP23, and VAMP2. Here we have used an in situ proximity ligation assay to integrate these two observations by demonstrating for the first time that insulin stimulation causes an ...[more]