Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay.
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ABSTRACT:
SUBMITTER: Meyer T
PROVIDER: S-EPMC3993695 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
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Improved detection of bacterial central nervous system infections by use of a broad-range PCR assay.
Meyer T T Franke G G Polywka S K A SK Lütgehetmann M M Gbadamosi J J Magnus T T Aepfelbacher M M
Journal of clinical microbiology 20140312 5
A universal PCR assay for bacteria and fungi detected meningitis pathogens in 65% of 20 cerebrospinal fluid (CSF) samples from patients with suspected central nervous system (CNS) infections compared to a 35% detection rate by culture and/or microscopy methods. Thus, the PCR assay can improve the diagnosis rate of infective meningitis when standard methods provide a negative result. ...[more]
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