Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a).
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ABSTRACT:
SUBMITTER: Pernet O
PROVIDER: S-EPMC3993810 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Publications
Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a).
Pernet Olivier O Beaty Shannon S Lee Benhur B
Journal of virology 20140212 9
Recent evidence identified multiple Henipavirus species in Africa distinct from those in Southeast Asia and Australia. The reported fusion glycoprotein (F) sequence of the African Gh-M74a strain (GhV-F) is likely incorrect: a single base pair deletion near the N terminus results in multiple aberrancies. Rectifying this by adding single nucleotide insertions results in a GhV-F that now possesses a signal peptide, is efficiently cell surface expressed, exhibits syncytium formation when coexpressed ...[more]
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