Ontology highlight
ABSTRACT:
SUBMITTER: Lu L
PROVIDER: S-EPMC3994537 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Lu Lei L Barfejani Arnavaz Hajizadeh AH Qin Tao T Dong Qiang Q Ayata Cenk C Waeber Christian C
Brain research 20140203
Recent studies have shown that fingolimod (FTY720) is neuroprotective in CNS injury models of cerebral ischemia and spinal cord injury. The purpose of the study was to examine the effect of fingolimod in a mouse model of intracerebral hemorrhage. ICH was produced in adult CD1 mice by injecting collagenase VII-S (0.5 µL, 0.06 U) into the basal ganglia. Fingolimod (or saline) was given 30 min after surgery and once daily for two days. Three days after intracerebral hemorrhage, brain edema, hematom ...[more]