Regional brain volumes and cognition in childhood epilepsy: does size really matter?

ABSTRACT:

Purpose

Recent studies have correlated neurocognitive function and regional brain volumes in children with epilepsy. We tested whether brain volume differences between children with and without epilepsy explained differences in neurocognitive function.

Methods

The study sample included 108 individuals with uncomplicated non-syndromic epilepsy (NSE) and 36 healthy age- and gender-matched controls. Participants received a standardized cognitive battery. Whole brain T1-weighted MRI was obtained and volumes analyzed with FreeSurfer (TM).

Key findings

Total brain volume (TBV) was significantly smaller in cases. After adjustment for TBV, cases had significantly larger regional grey matter volumes for total, frontal, parietal, and precentral cortex. Cases had poorer performa

SUBMITTER: Zelko FA 

PROVIDER: S-EPMC3994880 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature