Vitamin D receptor regulates intestinal proteins involved in cell proliferation, migration and stress response.

ABSTRACT:

Background

Genome-wide association studies found low plasma levels of 25-hydroxyvitamin D and vitamin D receptor (VDR) polymorphisms associated with a higher prevalence of pathological changes in the intestine such as chronic inflammatory bowel diseases.

Methods

In this study, a proteomic approach was applied to understand the overall physiological importance of vitamin D in the small intestine, beyond its function in calcium and phosphate absorption.

Results

In total, 569 protein spots could be detected by two-dimensional-difference in-gel electrophoresis (2D-DIGE), and 82 proteins were considered as differentially regulated in the intestinal mucosa of VDR-deficient mice compared to that of wildtype (WT) mice. Fourteen clearly detectable proteins were identified by M

SUBMITTER: Kuhne H 

PROVIDER: S-EPMC3994967 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature