Ontology highlight
ABSTRACT:
SUBMITTER: Fruman DA
PROVIDER: S-EPMC3994981 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Fruman David A DA Rommel Christian C
Nature reviews. Drug discovery 20140201 2
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and mammalian target of rapamycin (mTOR) in cancer. However, emerging clinical data show limited single-agent activity of inhibitors targeting PI3K, AKT or mTOR at tolerated doses. One exception is the response to PI3Kδ inhibitors in chronic lymphocytic leukaemia, where a combination of cell-intrinsic and -extrinsic activities ...[more]