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Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

ABSTRACT: Trimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2 years. There were no differences in the body weights and survival in the treated animals compared to controls. Nonneoplastic skin lesions at the site of application included epidermal hyperplasia and hyperkeratosis in both rats and mice. There were no incidences of tumors at the site of application in rats and mice. Rare malignant liver neoplasms were observed in female mice that included hepatoblastoma in the 0.3 and 3.0mg/kg groups, and hepatocholangiocarcinoma in the 1.0 and 3.0mg/kg groups. The incidences of uterine stromal polyp and stromal polyp or stromal sarcoma (combined) in female mice occurred with positive trends and the incidences were significantly increased in the 3.0mg/kg group. A marginal increase in the incidences of malignant mesothelioma in male rats may have been related to TMPTA treatment. In conclusion, our studies show that TMPTA is a dermal irritant in both rats and mice of either sex. Increased incidences of tumor formation were observed in female mice and male rats.

SUBMITTER: Surh I

PROVIDER: S-EPMC3995139 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature

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Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

Surh Inok I Rao Deepa B DB Cesta Mark F MF Hébert Charles D CD Mann Jill F JF Cunny Helen H Kissling Grace E GE Malarkey David D Chhabra Rajendra S RS

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20140203

Trimethylolpropane triacrylate (TMPTA) is a multifunctional monomer with industrial applications. To determine the carcinogenic potential, male and female F344/N rats and B6C3F1/N mice were administered TMPTA (0, 0.3, 1.0, or 3.0mg/kg) in acetone dermally for 2 years. There were no differences in the body weights and survival in the treated animals compared to controls. Nonneoplastic skin lesions at the site of application included epidermal hyperplasia and hyperkeratosis in both rats and mice. ...[more]

PMID: 24503412

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Dataset Information

Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

Publications

Species and gender differences in the carcinogenic activity of trimethylolpropane triacrylate in rats and mice.

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