Ontology highlight
ABSTRACT:
SUBMITTER: Skrnjug I
PROVIDER: S-EPMC3996008 | biostudies-literature | 2014
REPOSITORIES: biostudies-literature
Škrnjug Ivana I Rueckert Christine C Libanova Rimma R Lienenklaus Stefan S Weiss Siegfried S Guzmán Carlos A CA
PloS one 20140422 4
The cyclic di-nucleotide bis-(3',5')-cyclic dimeric adenosine monophosphate (c-di-AMP) is a candidate mucosal adjuvant with proven efficacy in preclinical models. It was shown to promote specific humoral and cellular immune responses following mucosal administration. To date, there is only fragmentary knowledge on the cellular and molecular mode of action of c-di-AMP. Here, we report on the identification of dendritic cells and macrophages as target cells of c-di-AMP. We show that c-di-AMP induc ...[more]