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Nylon-3 polymers that enable selective culture of endothelial cells.


ABSTRACT: Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomaterials-based approaches to tissue repair or regeneration. However, there are very few examples of synthetic materials that display selectivity in supporting cell growth. We describe nylon-3 polymers that support in vitro culture of endothelial cells but do not support the culture of smooth muscle cells or fibroblasts. These materials may be promising for vascular biomaterials applications.

SUBMITTER: Liu R 

PROVIDER: S-EPMC3996459 | biostudies-literature | 2013 Nov

REPOSITORIES: biostudies-literature

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Nylon-3 polymers that enable selective culture of endothelial cells.

Liu Runhui R   Chen Xinyu X   Gellman Samuel H SH   Masters Kristyn S KS  

Journal of the American Chemical Society 20131101 44


Substrates that selectively encourage the growth of specific cell types are valuable for the engineering of complex tissues. Some cell-selective peptides have been identified from extracellular matrix proteins; these peptides have proven useful for biomaterials-based approaches to tissue repair or regeneration. However, there are very few examples of synthetic materials that display selectivity in supporting cell growth. We describe nylon-3 polymers that support in vitro culture of endothelial c  ...[more]

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