Ontology highlight
ABSTRACT:
SUBMITTER: Manzoni G
PROVIDER: S-EPMC3996467 | biostudies-literature | 2014 Apr
REPOSITORIES: biostudies-literature
Manzoni Giulia G Briquet Sylvie S Risco-Castillo Veronica V Gaultier Charlotte C Topçu Selma S Ivănescu Maria Larisa ML Franetich Jean-François JF Hoareau-Coudert Bénédicte B Mazier Dominique D Silvie Olivier O
Scientific reports 20140423
Experimental genetics have been widely used to explore the biology of the malaria parasites. The rodent parasites Plasmodium berghei and less frequently P. yoelii are commonly utilised, as their complete life cycle can be reproduced in the laboratory and because they are genetically tractable via homologous recombination. However, due to the limited number of drug-selectable markers, multiple modifications of the parasite genome are difficult to achieve and require large numbers of mice. Here we ...[more]