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Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.

ABSTRACT: Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit, loading its contents, pinching off the membrane as a lattice-enclosed vesicle, and recycling the components. It integrates as much of the structural information as possible at the time of writing into a sketch of the principal steps in coated-pit and coated-vesicle formation.

SUBMITTER: Kirchhausen T

PROVIDER: S-EPMC3996469 | biostudies-literature | 2014 May

REPOSITORIES: biostudies-literature

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Molecular structure, function, and dynamics of clathrin-mediated membrane traffic.

Kirchhausen Tom T Owen David D Harrison Stephen C SC

Cold Spring Harbor perspectives in biology 20140501 5

Clathrin is a molecular scaffold for vesicular uptake of cargo at the plasma membrane, where its assembly into cage-like lattices underlies the clathrin-coated pits of classical endocytosis. This review describes the structures of clathrin, major cargo adaptors, and other proteins that participate in forming a clathrin-coated pit, loading its contents, pinching off the membrane as a lattice-enclosed vesicle, and recycling the components. It integrates as much of the structural information as pos ...[more]

PMID: 24789820

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