Ontology highlight
ABSTRACT:
SUBMITTER: Jespersen A
PROVIDER: S-EPMC3997178 | biostudies-literature | 2014 Jan
REPOSITORIES: biostudies-literature
Jespersen Annie A Tajima Nami N Fernandez-Cuervo Gabriela G Garnier-Amblard Ethel C EC Furukawa Hiro H
Neuron 20140101 2
There has been a great level of enthusiasm to downregulate overactive N-methyl-D-aspartate (NMDA) receptors to protect neurons from excitotoxicity. NMDA receptors play pivotal roles in basic brain development and functions as well as in neurological disorders and diseases. However, mechanistic understanding of antagonism in NMDA receptors is limited due to complete lack of antagonist-bound structures for the L-glutamate-binding GluN2 subunits. Here, we report the crystal structures of GluN1/GluN ...[more]