Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.
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ABSTRACT:
SUBMITTER: Lu K
PROVIDER: S-EPMC3997221 | biostudies-literature | 2014 Feb
REPOSITORIES: biostudies-literature
Publications
Gut microbiome phenotypes driven by host genetics affect arsenic metabolism.
Lu Kun K Mahbub Ridwan R Cable Peter Hans PH Ru Hongyu H Parry Nicola M A NM Bodnar Wanda M WM Wishnok John S JS Styblo Miroslav M Swenberg James A JA Fox James G JG Tannenbaum Steven R SR
Chemical research in toxicology 20140203 2
Large individual differences in susceptibility to arsenic-induced diseases are well-documented and frequently associated with different patterns of arsenic metabolism. In this context, the role of the gut microbiome in directly metabolizing arsenic and triggering systemic responses in diverse organs raises the possibility that gut microbiome phenotypes affect the spectrum of metabolized arsenic species. However, it remains unclear how host genetics and the gut microbiome interact to affect the b ...[more]
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